Now you can do something for your geriatric feline patients!!
Plena Curae has a new renal support formula for cats and small dogs with renal insufficiency. The active
ingredients are Rehmennia and Astragulas, well known herbs for renal support, in a highly palatable base of chicken and other food ingredients.
Each chew contains adaptogen herbs known to aid in kidney function:
60 mg Astragalus
30 mg Rehmennia
Astragalus: An astragalus-based TCM formula was shown to preserve residual renal
function dialysis patients and to reduce proteinuria associated with idiopathic
membranous nephropathy. A systematic review concluded that adjunctive use of
astragalus in addition to conventional therapies may be effective for short-term reductions of albuminuria, proteinuria, and serum creatinine in patients with diabetic kidney disease.
Ahmed MS, Hou SH, Battaglia MC, et al. Treatment of idiopathic membranous nephropathy with the herb Astragalus membranaceus. Am J Kidney Dis. Dec 2007;50(6):1028-1032. Lui SL, Zhu D, Cheng SW, et al. Effects of Astragalus membranaceus-based Chinese Medicine Formulae on Residual Renal Function in Patients on Peritoneal Dialysis. Perit Dial Int. Sep-Oct 2015;35(5):595-597. Zhang, Shergis JL, Yang L, et al. Astragalus membranaceus (Huang Qi) as adjunctive therapy for diabetic kidney disease: An updated systematic review and meta-analysis. J Ethnopharmacol. 2019 Jul 15;239:111921.Ahmed MS, Hou SH, Battaglia MC, et al. Treatment of idiopathic membranous nephropathy with the herb Astragalus membranaceus. Am J Kidney Dis. Dec 2007;50(6):1028-1032.Lui SL, Zhu D, Cheng SW, et al. Effects of Astragalus membranaceus-based Chinese Medicine Formulae on Residual Renal Function in Patients on Peritoneal Dialysis. Perit Dial Int. Sep-Oct 2015;35(5):595-597.Zhang, Shergis JL, Yang L, et al. Astragalus membranaceus (Huang Qi) as adjunctive therapy for diabetic kidney disease: An updated systematic review and meta-analysis. J Ethnopharmacol. 2019 Jul 15;239:111921.
Rehmennia: Rehmannia glutinosa reduced the serum creatinine level, 24-h urinary protein excretion, and glomerulosclerosis, and it also inhibited the expression of angiotensin II, AT(1) receptor, TGF-beta1 and type IV collagen in the renal cortex. These results suggest that the reno-protective effect of Rehmannia glutinosa might be mediated by suppressing the expression of angiotensin II and AT(1) receptor and by regulating TGF-beta1 and type IV collagen expression.
Lee et al.: Rehmannia glutinosa ameliorates the progressive renal failure induced by 5/6 nephrectomy. J Ethnopharmacol 2009 Feb 25;122(1):131-5. Kang, et al: Rehmannia glutinosa ameliorates renal function in the ischemia/ reperfusion induced acute renal failure rats. Biol. Pharm. Bull. 28(9) 1662—1667 (2005)Lee et al.: Rehmannia glutinosa ameliorates the progressive renal failure induced by 5/6 nephrectomy. J Ethnopharmacol 2009 Feb 25;122(1):131-5.Kang, et al: Rehmannia glutinosa ameliorates renal function in the ischemia/ reperfusion induced acute renal failure rats. Biol. Pharm. Bull. 28(9) 1662—1667 (2005)
The renal chews come in a 3.5 oz (99g) tub which will last approximately 50 days for the average cat, 25 days for a 15-20 lb dog. Dosing is SID, and taste testers agree—- cats love them